prikaz prve stranice dokumenta Validation of the new diagnostic criteria for clinically significant portal hypertension by platelets and elastography
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Scientific paper - Original scientific paper
Validation of the new diagnostic criteria for clinically significant portal hypertension by platelets and elastography
Digestive Diseases and Sciences, 67 (2021), 7; 3327-3332. https://doi.org/10.1007/s10620-021-07277-8
Podrug, Kristian; Trkulja, Vladimir; Zelenika, Marko; Bokun, Tomislav; Madir, Anita; Kanizaj, Tajana Filipec; O’Beirne, James; Grgurevic, Ivica

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Podrug, K., Trkulja, V., Zelenika, M., Bokun, T., Madir, A., Kanizaj, T. F. ... Grgurevic, I. (2021). Validation of the new diagnostic criteria for clinically significant portal hypertension by platelets and elastography. Digestive Diseases and Sciences, 67. (7), 3327-3332. doi: 10.1007/s10620-021-07277-8

Podrug, Kristian, et al. "Validation of the new diagnostic criteria for clinically significant portal hypertension by platelets and elastography." Digestive Diseases and Sciences, vol. 67, no. 7, 2021, pp. 3327-3332. https://doi.org/10.1007/s10620-021-07277-8

Podrug, Kristian, Vladimir Trkulja, Marko Zelenika, Tomislav Bokun, Anita Madir, Tajana Filipec Kanizaj, James O’Beirne and Ivica Grgurevic. "Validation of the new diagnostic criteria for clinically significant portal hypertension by platelets and elastography." Digestive Diseases and Sciences 67, no. 7 (2021): 3327-3332. https://doi.org/10.1007/s10620-021-07277-8

Podrug, K., et al. (2021) 'Validation of the new diagnostic criteria for clinically significant portal hypertension by platelets and elastography', Digestive Diseases and Sciences, 67(7), pp. 3327-3332. doi: 10.1007/s10620-021-07277-8

Podrug K, Trkulja V, Zelenika M, Bokun T, Madir A, Kanizaj TF, and sur.. Validation of the new diagnostic criteria for clinically significant portal hypertension by platelets and elastography. Digestive Diseases and Sciences [Internet]. 2021 November 05 [cited 2024 December 19];67(7):3327-3332. doi: 10.1007/s10620-021-07277-8

K. Podrug, et al., "Validation of the new diagnostic criteria for clinically significant portal hypertension by platelets and elastography", Digestive Diseases and Sciences, vol. 67, no. 7, pp. 3327-3332, November 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:264:591863. [Accessed: 19 December 2024]

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Metadata
Title (english)Validation of the new diagnostic criteria for clinically significant portal hypertension by platelets and elastography
AuthorKristian Podrug
AuthorVladimir Trkulja
AuthorMarko Zelenika
AuthorTomislav Bokun
AuthorAnita Madir
AuthorTajana Filipec Kanizaj
AuthorJames O’Beirne
AuthorIvica Grgurevic
Author's institution(Merkur University Hospital)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background and Aims We aimed to validate newly proposed noninvasive criteria for diagnosing clinically signifcant portal hypertension (CSPH) using liver stifness measurements (LSM) by transient elastography (TE) and platelet count. Methods Diagnostic performance of these new criteria for CSPH (LSM≥25 kPa to rule in and Plt≥150× 109 /L+LSM≤1 5 kPa to rule out CSPH) were retrospectively tested in an independent cohort of consecutive patients who underwent hepatic venous pressure gradient (HVPG) measurements and liver biopsy due to suspicion of compensated advanced chronic liver disease. Suspicion of cACLD was based on LSM≥10 kPa by TE or results of liver imaging, without overt signs of CSPH. Patients with conditions known to afect results of LSM (ALT>5×ULN, liver congestion, extrahepatic biliary obstruction, infltrative liver neoplasms) were excluded. Results Seventy six (76) patients were included: 78.9% males, mean age 62 years, 36.8% sufered from alcoholic, 30.3% nonalcoholic fatty liver disease, 14.5% chronic viral hepatitis, 30.3% were obese, 52.6% had HVPG≥10 mmHg, 56.6% had platelet count≥150× 109 /L. LSM≥25 kPa had 88.9% specifcity (95% CI 73.9– 96.9) to rule in, whereas Plt≥150+LSM≤15 kPa had 100% sensitivity (95% CI 91.1–100) to rule out CSPH. Conclusion By using these simple noninvasive criteria 49/76 (64.5%) patients could be classifed correctly for the presence/ absence of CSPH, thus obviating the need for HVPG measurements.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDigestive Diseases and Sciences
Numberingvol. 67, no. 7, pp. 3327-3332
p-ISSN0163-2116
DOIhttps://doi.org/10.1007/s10620-021-07277-8
URN:NBNurn:nbn:hr:264:591863
Publication2021-11-05
Document URLhttps://link.springer.com/article/10.1007/s10620-021-07277-8
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-12-20 10:03:40