prikaz prve stranice dokumenta Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation
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Scientific paper - Conference abstract (invited lecture)
Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation
In: Transplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013. Wiley, 2013. pp. 138. urn:nbn:hr:264:049283
Mikulić, Danko; Knotek, Mladen; Gašparov, Slavko; Mrzljak, Anna; Škrtić, Anita; Čolić Cvrlje, Vesna; Jadrijević, Stipislav; Branislav, Kocman

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Mikulić, D., Knotek, M., Gašparov, S., Mrzljak, A., Škrtić, A., Čolić Cvrlje, V. ... Branislav, K. (2013). Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation. Transplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013 (p. 138). Wiley. Retrieved from https://urn.nsk.hr/urn:nbn:hr:264:049283

Mikulić, Danko, et al. "Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation." Transplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013, Wiley, 2013, p. 138. https://urn.nsk.hr/urn:nbn:hr:264:049283

Mikulić, Danko, Mladen Knotek, Slavko Gašparov, Anna Mrzljak, Anita Škrtić, Vesna Čolić Cvrlje, Stipislav Jadrijević and Kocman Branislav. "Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation." In Transplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013, 138. Wiley, 2013. Accessed 2024 November 23. https://urn.nsk.hr/urn:nbn:hr:264:049283

Mikulić, D., et al. (2013) 'Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation', Transplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013, Wiley, p. 138. Available at: https://urn.nsk.hr/urn:nbn:hr:264:049283 (Accessed 23 November 2024)

Mikulić D, Knotek M, Gašparov S, Mrzljak A, Škrtić A, Čolić Cvrlje V, and sur.. Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation. Transplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013. Wiley; 2013. Pp. 138-138. [cited 2024 November 23] Available at: https://urn.nsk.hr/urn:nbn:hr:264:049283

D. Mikulić, et al., "Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation", Transplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013 Wiley, 2013. [Online] Available at: https://urn.nsk.hr/urn:nbn:hr:264:049283 [Accessed: 23 November 2024]

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Metadata
Title (english)Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation
AuthorDanko Mikulić
AuthorMladen Knotek
AuthorSlavko Gašparov
AuthorAnna Mrzljak
AuthorAnita Škrtić
AuthorVesna Čolić Cvrlje
AuthorStipislav Jadrijević
AuthorKocman Branislav
Author's institution(Merkur University Hospital)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background: Liver transplantation (LT) is an established treatment method in patients with hepatocellular carcinoma (HCC). However, a number of patients experience early recurrence and poor results as a consequence of aggressive tumor biology. Due to the ever increasing organ shortage, new biologic prognostic factors are necessary in order to stratify the patients regarding prognosis. Methods: 44 patients with HCC treated by LT were included in this retrospective study. Analyzed clinical and pathologic data include age, sex, number and size of tumors, tumor differentiation, presence of vascular invasion, adherence to Milan criteria, alpha-fetoprotein level. Immunostaining was used to assess the infiltration of CD3+, CD4+, CD8+ and Foxp3+ cells. Kaplan Meier curves and receiver operator characteristic (ROC) analysis were used to analyze recurrence free and overall survival. Results: Presence of microvascular invasion was found to be associated with HCC recurrence (p=0.035). Analysis of immune parameters showed that the patients with increased total lymphocyte infiltration measured by the number of tumor infiltrating CD3+ cells are less likely to experience recurrence (p=0.05). ROC curve analysis showed that patients with a CD4/CD8 ratio greater than 1 had better chances of recurrence free survival. Also, patients with lower numbers of infiltrating T reg cells were found less likely to experience HCC recurrence (p=0.025). Conclusion: Our results indicate that total lymphocyte infiltration, CD4/CD8 ratio and T reg infiltration have prognostic significance in HCC. These parameters could add valuable information to the presently used morphologic criteria in order to stratify HCC patients who benefit from liver transplantation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Conference abstract (invited lecture)
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Publication titleTransplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013
Numberingvol. 26, no. Suppl. 2, p. 138
p-ISSN0934-0874
e-ISSN1432-2277
URN:NBNurn:nbn:hr:264:049283
Publication2013
ConferenceTitle: 16th Congress of the European Society for Organ Transplantation
Acronym: 16th ESOT Congress
Location: Beč, Austria
Start date: 2013-09-08
End date: 2013-09-11
Assembly type: Lecture
Document URLhttps://onlinelibrary.wiley.com/toc/14322277/2013/26/s2
Type of resourceText
PublisherWiley
Access conditionsOpen access
Terms of useLicence Attribution 3.0 Unported (CC BY 3.0) icon
Created on2022-12-28 07:48:43