prikaz prve stranice dokumenta N-glycosylation of immunoglobulin A in children and adults with type 1 diabetes mellitus
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Scientific paper - Original scientific paper
N-glycosylation of immunoglobulin A in children and adults with type 1 diabetes mellitus
Heliyon, 10 (2024), 9; e30529. https://doi.org/10.1016/j.heliyon.2024.e30529
Nemčić, Matej; Shkunnikova, Sofia; Kifer, Domagoj; Plavša, Branimir; Vučić Lovrenčić, Marijana; Morahan, Grant; Duvnjak, Lea; Pociot, Flemming; Gornik, Olga

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Nemčić, M., Shkunnikova, S., Kifer, D., Plavša, B., Vučić Lovrenčić, M., Morahan, G. ... Gornik, O. (2024). N-glycosylation of immunoglobulin A in children and adults with type 1 diabetes mellitus. Heliyon, 10. (9), e30529. doi: 10.1016/j.heliyon.2024.e30529

Nemčić, Matej, et al. "N-glycosylation of immunoglobulin A in children and adults with type 1 diabetes mellitus." Heliyon, vol. 10, no. 9, 2024, p. e30529. https://doi.org/10.1016/j.heliyon.2024.e30529

Nemčić, Matej, Sofia Shkunnikova, Domagoj Kifer, Branimir Plavša, Marijana Vučić Lovrenčić, Grant Morahan, Lea Duvnjak, Flemming Pociot and Olga Gornik. "N-glycosylation of immunoglobulin A in children and adults with type 1 diabetes mellitus." Heliyon 10, no. 9 (2024): e30529. https://doi.org/10.1016/j.heliyon.2024.e30529

Nemčić, M., et al. (2024) 'N-glycosylation of immunoglobulin A in children and adults with type 1 diabetes mellitus', Heliyon, 10(9), p. e30529. doi: 10.1016/j.heliyon.2024.e30529

Nemčić M, Shkunnikova S, Kifer D, Plavša B, Vučić Lovrenčić M, Morahan G, and sur.. N-glycosylation of immunoglobulin A in children and adults with type 1 diabetes mellitus. Heliyon [Internet]. 2024 May [cited 2025 April 04];10(9):e30529. doi: 10.1016/j.heliyon.2024.e30529

M. Nemčić, et al., "N-glycosylation of immunoglobulin A in children and adults with type 1 diabetes mellitus", Heliyon, vol. 10, no. 9, p. e30529, May 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:264:919828. [Accessed: 04 April 2025]

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Metadata
Title (english)N-glycosylation of immunoglobulin A in children and adults with type 1 diabetes mellitus
AuthorMatej Nemčić
AuthorSofia Shkunnikova
AuthorDomagoj Kifer
AuthorBranimir Plavša
AuthorMarijana Vučić Lovrenčić
AuthorGrant Morahan
AuthorLea Duvnjak
AuthorFlemming Pociot
AuthorOlga Gornik
Author's institution(Merkur University Hospital)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Aims: To identify N-glycan structures on immunoglobulin A related to type 1 diabetes mellitus among children at the disease onset and adults with type 1 diabetes mellitus. Methods: Human polyclonal IgA N-glycans were profiled using hydrophilic interaction ultra performance liquid chromatography in two cohorts. The first cohort consisted of 62 children at the onset of type 1 diabetes mellitus and 86 of their healthy siblings. The second cohort contained 84 adults with the disease and 84... More controls. Associations between N-glycans and type 1 diabetes mellitus were tested using linear mixed model for the paediatric cohort, or general linear model for the adult cohort. False discovery rate was controlled by Benjamini-Hochberg method modified by Li and Ji. Results: In children, an increase in a single oligomannose N-glycan was associated with type 1 diabetes mellitus (B = 0.529, p = 0.0067). N-glycome of the adults displayed increased branching (B = 0.466, p = 0.0052), trigalactosylation (B = 0.466, p = 0.0052), trisialylation (B = 0.629, p < 0.001), and mannosylation (B = 0.604, p < 0.001). The strongest association with the disease was a decrease in immunoglobulin A core fucosylation (B = -0.900, p < 0.001). Conclusions: Changes in immunoglobulin N-glycosylation patterns in type 1 diabetes point to disruptions in immunoglobulin A catabolism and dysregulated inflammatory capabilities of the antibody, potentially impacting immune responses and inflammation. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleHeliyon
Numberingvol. 10, no. 9, p. e30529
p-ISSN2405-8440
DOIhttps://doi.org/10.1016/j.heliyon.2024.e30529
URN:NBNurn:nbn:hr:264:919828
Publication2024-05
Document URLhttps://www.sciencedirect.com/science/article/pii/S2405844024065605?via%3Dihub
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2025-03-13 11:53:46
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