prikaz prve stranice dokumenta Tonsil-derived mesenchymal stem cells exert immunosuppressive effects on T cells
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Scientific paper - Original scientific paper
Tonsil-derived mesenchymal stem cells exert immunosuppressive effects on T cells
Croatian Medical Journal, 60 (2019), 1; 12-19. https://doi.org/10.3325/cmj.2019.60.12
Bačić, Antun; Prgomet, Drago; Janjanin, Saša

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Bačić, A., Prgomet, D. & Janjanin, S. (2019). Tonsil-derived mesenchymal stem cells exert immunosuppressive effects on T cells. Croatian Medical Journal, 60. (1), 12-19. doi: 10.3325/cmj.2019.60.12

Bačić, Antun, et al. "Tonsil-derived mesenchymal stem cells exert immunosuppressive effects on T cells." Croatian Medical Journal, vol. 60, no. 1, 2019, pp. 12-19. https://doi.org/10.3325/cmj.2019.60.12

Bačić, Antun, Drago Prgomet and Saša Janjanin. "Tonsil-derived mesenchymal stem cells exert immunosuppressive effects on T cells." Croatian Medical Journal 60, no. 1 (2019): 12-19. https://doi.org/10.3325/cmj.2019.60.12

Bačić, A., Prgomet, D. and Janjanin, S. (2019) 'Tonsil-derived mesenchymal stem cells exert immunosuppressive effects on T cells', Croatian Medical Journal, 60(1), pp. 12-19. doi: 10.3325/cmj.2019.60.12

Bačić A, Prgomet D, Janjanin S. Tonsil-derived mesenchymal stem cells exert immunosuppressive effects on T cells. Croatian Medical Journal [Internet]. 2019 January [cited 2024 December 15];60(1):12-19. doi: 10.3325/cmj.2019.60.12

A. Bačić, D. Prgomet and S. Janjanin, "Tonsil-derived mesenchymal stem cells exert immunosuppressive effects on T cells", Croatian Medical Journal, vol. 60, no. 1, pp. 12-19, January 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:264:557804. [Accessed: 15 December 2024]

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Metadata
Title (english)Tonsil-derived mesenchymal stem cells exert immunosuppressive effects on T cells
AuthorAntun Bačić
AuthorDrago Prgomet
AuthorSaša Janjanin
Author's institution(Merkur University Hospital)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Abstract (english)
Aim To assess the immunomodulatory effect of tonsil-derived mesenchymal stem cells (MSCs) on T-lymphocyte proliferation and cytokine production. Methods Tonsils were obtained from children aged 3 to 12 years (n = 15) who underwent tonsillectomy for obstructive sleep apnea from April 2012-October 2014 at the Merkur University Hospital, Zagreb. Tonsil-derived MSCs were co-cultured with peripheral blood mononuclear cells (PBMCs) and phytohemagglutinin as a mitogen. PBMCs were induced to differentiate into T helper 1 or T helper 2 cells in the presence or absence of tonsil-derived MSCs, after which the production of interferon-gamma in T helper1 and interleukin-4 in T helper 2 cells was assessed. Results Tonsil-derived MSC suppressed phytohemagglutinin- induced proliferation of PBMCs. Compared with controls, tonsil-derived MSC co-culture significantly decreased interferon-gamma production (P < 0.001) and increased interleukin- 4 production (P < 0.001). Conclusion Tonsil-derived MSCs exert immunomodulatory effects on T lymphocyte proliferation and T helper 1- andT helper 2-specific cytokine production.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 60, no. 1, pp. 12-19
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2019.60.12
URN:NBNurn:nbn:hr:264:557804
Online first2019-01
Document URLhttp://www.cmj.hr/2019/60/1/30825273.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-05-11 11:36:58