prikaz prve stranice dokumenta Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157 : vascular recruitment and gastrointestinal tract healing
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Scientific paper - Original scientific paper
Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157 : vascular recruitment and gastrointestinal tract healing
Current Pharmaceutical Design, 24 (2018), 18; 1990-2001. https://doi.org/10.2174/1381612824666180608101119
Sikiric, Predrag; Rucman, Rudolf; Turkovic, Branko; Sever, Marko; Klicek, Robert; Radic, Bozo; Drmic, Domagoj; Stupnisek, Mirjana; Misic, Marija; Vuletic, Lovorka Batelja; Pavlov, Katarina Horvat; Barisic, Ivan; Kokot, Antonio; Peklic, Marina; Strbe, Sanja; Blagaic, Alenka Boban; Tvrdeic, Ante; Rokotov, Dinko Stancic; Vrcic, Hrvoje; Staresinic, Mario; Seiwerth, Sven More authors...

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Sikiric, P., Rucman, R., Turkovic, B., Sever, M., Klicek, R., Radic, B. ... Seiwerth, S. (2018). Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157 : vascular recruitment and gastrointestinal tract healing. Current Pharmaceutical Design, 24. (18), 1990-2001. doi: 10.2174/1381612824666180608101119

Sikiric, Predrag, et al. "Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157 : vascular recruitment and gastrointestinal tract healing." Current Pharmaceutical Design, vol. 24, no. 18, 2018, pp. 1990-2001. https://doi.org/10.2174/1381612824666180608101119

Sikiric, Predrag, Rudolf Rucman, Branko Turkovic, Marko Sever, Robert Klicek, Bozo Radic, Domagoj Drmic, et al. "Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157 : vascular recruitment and gastrointestinal tract healing." Current Pharmaceutical Design 24, no. 18 (2018): 1990-2001. https://doi.org/10.2174/1381612824666180608101119

Sikiric, P., et al. (2018) 'Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157 : vascular recruitment and gastrointestinal tract healing', Current Pharmaceutical Design, 24(18), pp. 1990-2001. doi: 10.2174/1381612824666180608101119

Sikiric P, Rucman R, Turkovic B, Sever M, Klicek R, Radic B, and sur.. Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157 : vascular recruitment and gastrointestinal tract healing. Current Pharmaceutical Design [Internet]. 2018 September 12 [cited 2025 April 04];24(18):1990-2001. doi: 10.2174/1381612824666180608101119

P. Sikiric, et al., "Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157 : vascular recruitment and gastrointestinal tract healing", Current Pharmaceutical Design, vol. 24, no. 18, pp. 1990-2001, September 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:264:429016. [Accessed: 04 April 2025]

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Metadata
Title (english)Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157 : vascular recruitment and gastrointestinal tract healing
AuthorPredrag Sikiric
AuthorRudolf Rucman
AuthorBranko Turkovic
AuthorMarko Sever
AuthorRobert Klicek
AuthorBozo Radic
AuthorDomagoj Drmic
AuthorMirjana Stupnisek
AuthorMarija Misic
AuthorLovorka Batelja Vuletic
AuthorKatarina Horvat Pavlov
AuthorIvan Barisic
AuthorAntonio Kokot
AuthorMarina Peklic
AuthorSanja Strbe
AuthorAlenka Boban Blagaic
AuthorAnte Tvrdeic
AuthorDinko Stancic Rokotov
AuthorHrvoje Vrcic
AuthorMario Staresinic
AuthorSven Seiwerth
Author's institution(Merkur University Hospital)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Years ago, we revealed a novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157, particular anti- ulcer peptide that heals different organs lesions when given as a therapy, native in human gastric juice while maintaining GI-tract mucosal integrity, already tested in trials (ulcerative colitis and now multiple sclerosis). The stomach cytoprotection is the most fundamental concept, stomach cell protection and endothelium protection are largely elaborated, but so far cell,... More protection and endothelium protection outside of the stomach were not implemented in the therapy. However, having managed these two points, stomach cell protection and endothelium protection, either one or together, even much more than standard cytoprotective agents do, BPC 157 employed large scale of its beneficial effects seen in various organs. Providing endothelium protection, BPC 157 was shown to prevent formation and reverse established thrombosis in anastomosed abdominal aorta as well as venous thrombosis after inferior caval vein occlusion, and attenuate bleeding prolongation and thrombocytopenia after amputation, without or with anticoagulants, or venous occlusion, and finally counteract effect of L-NAME and/or L-arginine. Now, with BPC 157 application, we reveal the third most important part of the cytoprotection concept: with the stomach cell and endothelium protection to recover mucosal integrity, BPC 157 as prototype cytoprotective agent should also control blood vessel function, depending upon injury, perforated defect or vessel obstruction. After a perforated injury (i.e., stomach), BPC 157 therapy activates blood vessels "running" towards defect. After obstruction (i.e., inferior caval vein), BPC 157 activates vessels "running" towards bypassing defect, collaterals functioning. Reestablished blood flow, and largely reversed injurious course may practically implement the cytoprotection concept. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCurrent Pharmaceutical Design
Numberingvol. 24, no. 18, pp. 1990-2001
p-ISSN1381-6128
e-ISSN1873-4286
DOIhttps://doi.org/10.2174/1381612824666180608101119
URN:NBNurn:nbn:hr:264:429016
Publication2018-09-12
Document URLhttps://www.eurekaselect.com/162924/article
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-12-27 10:14:32
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