prikaz prve stranice dokumenta CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma
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Scientific paper - Original scientific paper
CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma
Immunobiology, 227 (2022), 5; 152257. https://doi.org/10.1016/j.imbio.2022.152257
Gršković, Paula; Hančić, Suzana; Dotlić, Snježana; Matulić, Maja; Ostojić Kolonić, Slobodanka; Gašparov, Slavko; Dominis, Mara; Korać, Petra

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Gršković, P., Hančić, S., Dotlić, S., Matulić, M., Ostojić Kolonić, S., Gašparov, S. ... Korać, P. (2022). CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma. Immunobiology, 227. (5), 152257. doi: 10.1016/j.imbio.2022.152257

Gršković, Paula, et al. "CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma." Immunobiology, vol. 227, no. 5, 2022, p. 152257. https://doi.org/10.1016/j.imbio.2022.152257

Gršković, Paula, Suzana Hančić, Snježana Dotlić, Maja Matulić, Slobodanka Ostojić Kolonić, Slavko Gašparov, Mara Dominis and Petra Korać. "CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma." Immunobiology 227, no. 5 (2022): 152257. https://doi.org/10.1016/j.imbio.2022.152257

Gršković, P., et al. (2022) 'CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma', Immunobiology, 227(5), p. 152257. doi: 10.1016/j.imbio.2022.152257

Gršković P, Hančić S, Dotlić S, Matulić M, Ostojić Kolonić S, Gašparov S, and sur.. CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma. Immunobiology [Internet]. 2022 September [cited 2024 December 13];227(5):152257. doi: 10.1016/j.imbio.2022.152257

P. Gršković, et al., "CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma", Immunobiology, vol. 227, no. 5, p. 152257, September 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:264:732053. [Accessed: 13 December 2024]

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Metadata
Title (english)CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma
AuthorPaula Gršković
AuthorSuzana Hančić https://orcid.org/0000-0001-7864-7996
AuthorSnježana Dotlić
AuthorMaja Matulić
AuthorSlobodanka Ostojić Kolonić
AuthorSlavko Gašparov
AuthorMara Dominis
AuthorPetra Korać
Author's institution(Merkur University Hospital)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Follicular lymphoma is the second most frequent non-Hodgkin’s lymphoma, accounting for around 20 % of all lymphomas in Western countries. Initially, it behaves indolently, but in time becomes more aggressive and less susceptible to chemotherapy. Multiple features correlate with the survival of the patients and the progression of the disease, such as therapy with rituximab, tumour microenvironment and the intrafollicular proliferation index. Our research was focused on the association of specific components of tumour microenvironment and the tumour behaviour. The presence and the relative percentage of T lymphocytes, follicular dendritic cells, dendritic cells and macrophages was detected by immunohistochemical staining of the antigens specific for certain cell populations. Our results show that T lymphocytes and dendritic cells affect tumour growth, possibly through interactions with tumour cells. Higher patients’ ECOG score and the outcome of the disease are associated with the presence of CD14+ dendritic cells in tumour tissue, while the worse overall survival of patients is associated with the increased number of activated helper T lymphocytes that express marker of exhaustion CD57. Taken together, our results suggest that the efficiency of the immune response against follicular lymphoma depends on more than one type of immune cells. Also, we found that the phenotype of these cells, rather than just their number, affects the tumour behaviour and in consequence survival of the patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleImmunobiology
Numberingvol. 227, no. 5, p. 152257
p-ISSN0171-2985
DOIhttps://doi.org/10.1016/j.imbio.2022.152257
URN:NBNurn:nbn:hr:264:732053
Publication2022-09
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0171298522000833
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2024-12-10 08:02:01