prikaz prve stranice dokumenta CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma
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CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma
Immunobiology, 227 (2022), 5; 152257. https://doi.org/10.1016/j.imbio.2022.152257
Gršković, Paula; Hančić, Suzana; Dotlić, Snježana; Matulić, Maja; Ostojić Kolonić, Slobodanka; Gašparov, Slavko; Dominis, Mara; Korać, Petra

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Gršković, P., Hančić, S., Dotlić, S., Matulić, M., Ostojić Kolonić, S., Gašparov, S. ... Korać, P. (2022). CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma. Immunobiology, 227. (5), 152257. doi: 10.1016/j.imbio.2022.152257

Gršković, Paula, et al. "CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma." Immunobiology, vol. 227, br. 5, 2022, str. 152257. https://doi.org/10.1016/j.imbio.2022.152257

Gršković, Paula, Suzana Hančić, Snježana Dotlić, Maja Matulić, Slobodanka Ostojić Kolonić, Slavko Gašparov, Mara Dominis i Petra Korać. "CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma." Immunobiology 227, br. 5 (2022): 152257. https://doi.org/10.1016/j.imbio.2022.152257

Gršković, P., et al. (2022) 'CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma', Immunobiology, 227(5), str. 152257. doi: 10.1016/j.imbio.2022.152257

Gršković P, Hančić S, Dotlić S, Matulić M, Ostojić Kolonić S, Gašparov S, i sur.. CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma. Immunobiology [Internet]. 09.2022. [pristupljeno 13.12.2024.];227(5):152257. doi: 10.1016/j.imbio.2022.152257

P. Gršković, et al., "CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma", Immunobiology, vol. 227, br. 5, str. 152257, Rujan 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:264:732053. [Citirano: 13.12.2024.]

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Naslov (engleski)CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma
AutorPaula Gršković
AutorSuzana Hančić https://orcid.org/0000-0001-7864-7996
AutorSnježana Dotlić
AutorMaja Matulić
AutorSlobodanka Ostojić Kolonić
AutorSlavko Gašparov
AutorMara Dominis
AutorPetra Korać
Autorova ustanova(Klinička bolnica Merkur)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Follicular lymphoma is the second most frequent non-Hodgkin’s lymphoma, accounting for around 20 % of all lymphomas in Western countries. Initially, it behaves indolently, but in time becomes more aggressive and less susceptible to chemotherapy. Multiple features correlate with the survival of the patients and the progression of the disease, such as therapy with rituximab, tumour microenvironment and the intrafollicular proliferation index. Our research was focused on the association of specific components of tumour microenvironment and the tumour behaviour. The presence and the relative percentage of T lymphocytes, follicular dendritic cells, dendritic cells and macrophages was detected by immunohistochemical staining of the antigens specific for certain cell populations. Our results show that T lymphocytes and dendritic cells affect tumour growth, possibly through interactions with tumour cells. Higher patients’ ECOG score and the outcome of the disease are associated with the presence of CD14+ dendritic cells in tumour tissue, while the worse overall survival of patients is associated with the increased number of activated helper T lymphocytes that express marker of exhaustion CD57. Taken together, our results suggest that the efficiency of the immune response against follicular lymphoma depends on more than one type of immune cells. Also, we found that the phenotype of these cells, rather than just their number, affects the tumour behaviour and in consequence survival of the patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaImmunobiology
Brojčani podacivol. 227, br. 5, str. 152257
p-ISSN0171-2985
DOIhttps://doi.org/10.1016/j.imbio.2022.152257
URN:NBNurn:nbn:hr:264:732053
Datum objave publikacije2022-09
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0171298522000833
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2024-12-10 08:02:01