prikaz prve stranice dokumenta BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing
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Scientific paper - Review paper
BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing
Current Pharmaceutical Design, 24 (2018), 18; 1972-1989. https://doi.org/10.2174/1381612824666180712110447
Seiwerth, Sven; Rucman, Rudolf; Turkovic, Branko; Sever, Marko; Klicek, Robert; Radic, Bozo; Drmic, Domagoj; Stupnisek, Mirjana; Misic, Marija; Vuletic, Lovorka Batelja; Pavlov, Katarina Horvat; Barisic, Ivan; Kokot, Antonio; Japjec, Mladen; Blagaic, Alenka Boban; Tvrdeic, Ante; Rokotov, Dinko Stancic; Vrcic, Hrvoje; Staresinic, Mario; Sebecic, Bozidar; Sikiric, Predrag More authors...

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Seiwerth, S., Rucman, R., Turkovic, B., Sever, M., Klicek, R., Radic, B. ... Sikiric, P. (2018). BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing. Current Pharmaceutical Design, 24. (18), 1972-1989. doi: 10.2174/1381612824666180712110447

Seiwerth, Sven, et al. "BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing." Current Pharmaceutical Design, vol. 24, no. 18, 2018, pp. 1972-1989. https://doi.org/10.2174/1381612824666180712110447

Seiwerth, Sven, Rudolf Rucman, Branko Turkovic, Marko Sever, Robert Klicek, Bozo Radic, Domagoj Drmic, et al. "BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing." Current Pharmaceutical Design 24, no. 18 (2018): 1972-1989. https://doi.org/10.2174/1381612824666180712110447

Seiwerth, S., et al. (2018) 'BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing', Current Pharmaceutical Design, 24(18), pp. 1972-1989. doi: 10.2174/1381612824666180712110447

Seiwerth S, Rucman R, Turkovic B, Sever M, Klicek R, Radic B, and sur.. BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing. Current Pharmaceutical Design [Internet]. 2018 September 12 [cited 2025 April 02];24(18):1972-1989. doi: 10.2174/1381612824666180712110447

S. Seiwerth, et al., "BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing", Current Pharmaceutical Design, vol. 24, no. 18, pp. 1972-1989, September 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:264:909546. [Accessed: 02 April 2025]

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Title (english)BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing
AuthorSven Seiwerth
AuthorRudolf Rucman
AuthorBranko Turkovic
AuthorMarko Sever
AuthorRobert Klicek
AuthorBozo Radic
AuthorDomagoj Drmic
AuthorMirjana Stupnisek
AuthorMarija Misic
AuthorLovorka Batelja Vuletic
AuthorKatarina Horvat Pavlov
AuthorIvan Barisic
AuthorAntonio Kokot
AuthorMladen Japjec
AuthorAlenka Boban Blagaic
AuthorAnte Tvrdeic
AuthorDinko Stancic Rokotov
AuthorHrvoje Vrcic
AuthorMario Staresinic
AuthorBozidar Sebecic
AuthorPredrag Sikiric
Author's institution(Merkur University Hospital)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Commonly, the angiogenic growth factors signify healing. However, gastrointestinal ulceration is still poorly understood particularly with respect to a general pharmacological/pathophysiological role of various angiogenic growth factors implemented in growth factors wound healing concept. Thereby, we focused on the stable gastric pentadecapeptide BPC 157, a peptide given always alone vs. standard peptidergic angiogenic growth factors (EGF, FGF, VEGF), and numerous carriers. Further, we reviewed... More how the gastrointestinal tract healing could be generally perceived (i) in terms of angiogenic growth factors, and/or (ii) through the healing of extragastrointestinal tissues healing, such as tendon, ligament, muscle and bone, and vice versa. Respected were the beneficial effects obtained with free peptides or peptides with different carriers ; EGF, FGF, VEGF, and BPC 157, their presentation along with injuries, and a healing commonality, providing their implementation in both gastrointestinal ulcer healing and tendon, ligament, muscle and bone healing. Only BPC 157 was consistently effective in all of the models of acute/chronic injury of esophagus, stomach, duodenum and lower gastrointestinal tract, intraperitoneally, per-orally or locally. Unlike bFGF-, EGF-, VEGF-gastrointestinal tract studies demonstrating improved healing, most of the studies on tendon, muscle and bone injuries provide evidence of their (increased) presentation along with the various procedures used to produce beneficial effects, compared to fewer studies in vitro, while in vivo healing has a limited number of studies, commonly limited to local application, diverse healing evidence with diverse carriers and delivery systems. Contrary to this, BPC 157 - using same regimens like in gastrointestinal healing studies - improves tendon, ligament and bone healing, accurately implementing its own angiogenic effect in the healing. Thus, we claim that just BPC 157 represents in practice a pharmacological and pathophysiological role of various peptidergic growth factors. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCurrent Pharmaceutical Design
Numberingvol. 24, no. 18, pp. 1972-1989
p-ISSN1381-6128
e-ISSN1873-4286
DOIhttps://doi.org/10.2174/1381612824666180712110447
URN:NBNurn:nbn:hr:264:909546
Publication2018-09-12
Document URLhttps://www.eurekaselect.com/163708/article
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-12-27 10:22:56
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