prikaz prve stranice dokumenta BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing
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BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing
Current Pharmaceutical Design, 24 (2018), 18; 1972-1989. https://doi.org/10.2174/1381612824666180712110447
Seiwerth, Sven; Rucman, Rudolf; Turkovic, Branko; Sever, Marko; Klicek, Robert; Radic, Bozo; Drmic, Domagoj; Stupnisek, Mirjana; Misic, Marija; Vuletic, Lovorka Batelja; Pavlov, Katarina Horvat; Barisic, Ivan; Kokot, Antonio; Japjec, Mladen; Blagaic, Alenka Boban; Tvrdeic, Ante; Rokotov, Dinko Stancic; Vrcic, Hrvoje; Staresinic, Mario; Sebecic, Bozidar; Sikiric, Predrag Više autora...

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Seiwerth, S., Rucman, R., Turkovic, B., Sever, M., Klicek, R., Radic, B. ... Sikiric, P. (2018). BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing. Current Pharmaceutical Design, 24. (18), 1972-1989. doi: 10.2174/1381612824666180712110447

Seiwerth, Sven, et al. "BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing." Current Pharmaceutical Design, vol. 24, br. 18, 2018, str. 1972-1989. https://doi.org/10.2174/1381612824666180712110447

Seiwerth, Sven, Rudolf Rucman, Branko Turkovic, Marko Sever, Robert Klicek, Bozo Radic, Domagoj Drmic, et al. "BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing." Current Pharmaceutical Design 24, br. 18 (2018): 1972-1989. https://doi.org/10.2174/1381612824666180712110447

Seiwerth, S., et al. (2018) 'BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing', Current Pharmaceutical Design, 24(18), str. 1972-1989. doi: 10.2174/1381612824666180712110447

Seiwerth S, Rucman R, Turkovic B, Sever M, Klicek R, Radic B, i sur.. BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing. Current Pharmaceutical Design [Internet]. 12.09.2018. [pristupljeno 04.04.2025.];24(18):1972-1989. doi: 10.2174/1381612824666180712110447

S. Seiwerth, et al., "BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing", Current Pharmaceutical Design, vol. 24, br. 18, str. 1972-1989, Rujan 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:264:909546. [Citirano: 04.04.2025.]

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Naslov (engleski)BPC 157 and standard angiogenic growth factors : gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing
AutorSven Seiwerth
AutorRudolf Rucman
AutorBranko Turkovic
AutorMarko Sever
AutorRobert Klicek
AutorBozo Radic
AutorDomagoj Drmic
AutorMirjana Stupnisek
AutorMarija Misic
AutorLovorka Batelja Vuletic
AutorKatarina Horvat Pavlov
AutorIvan Barisic
AutorAntonio Kokot
AutorMladen Japjec
AutorAlenka Boban Blagaic
AutorAnte Tvrdeic
AutorDinko Stancic Rokotov
AutorHrvoje Vrcic
AutorMario Staresinic
AutorBozidar Sebecic
AutorPredrag Sikiric
Autorova ustanova(Klinička bolnica Merkur)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Commonly, the angiogenic growth factors signify healing. However, gastrointestinal ulceration is still poorly understood particularly with respect to a general pharmacological/pathophysiological role of various angiogenic growth factors implemented in growth factors wound healing concept. Thereby, we focused on the stable gastric pentadecapeptide BPC 157, a peptide given always alone vs. standard peptidergic angiogenic growth factors (EGF, FGF, VEGF), and numerous carriers. Further, we reviewed... Više how the gastrointestinal tract healing could be generally perceived (i) in terms of angiogenic growth factors, and/or (ii) through the healing of extragastrointestinal tissues healing, such as tendon, ligament, muscle and bone, and vice versa. Respected were the beneficial effects obtained with free peptides or peptides with different carriers ; EGF, FGF, VEGF, and BPC 157, their presentation along with injuries, and a healing commonality, providing their implementation in both gastrointestinal ulcer healing and tendon, ligament, muscle and bone healing. Only BPC 157 was consistently effective in all of the models of acute/chronic injury of esophagus, stomach, duodenum and lower gastrointestinal tract, intraperitoneally, per-orally or locally. Unlike bFGF-, EGF-, VEGF-gastrointestinal tract studies demonstrating improved healing, most of the studies on tendon, muscle and bone injuries provide evidence of their (increased) presentation along with the various procedures used to produce beneficial effects, compared to fewer studies in vitro, while in vivo healing has a limited number of studies, commonly limited to local application, diverse healing evidence with diverse carriers and delivery systems. Contrary to this, BPC 157 - using same regimens like in gastrointestinal healing studies - improves tendon, ligament and bone healing, accurately implementing its own angiogenic effect in the healing. Thus, we claim that just BPC 157 represents in practice a pharmacological and pathophysiological role of various peptidergic growth factors. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCurrent Pharmaceutical Design
Brojčani podacivol. 24, br. 18, str. 1972-1989
p-ISSN1381-6128
e-ISSN1873-4286
DOIhttps://doi.org/10.2174/1381612824666180712110447
URN:NBNurn:nbn:hr:264:909546
Datum objave publikacije2018-09-12
URL dokumentahttps://www.eurekaselect.com/163708/article
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-12-27 10:22:56
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