prikaz prve stranice dokumenta Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application
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Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application
Medical science monitor, 16 (2010), 3; 81-88. urn:nbn:hr:264:547766
Pevec, Damira; Novinščak, Tomislac; Brčić, Luka; Šipoš, Kristijan; Jukić, Ivana; Starešinić, Mario; Miše, Stjepan; Brčić, Iva; Kolenc, Danijela; Kliček, Robert; Banić, Tihomir; Sever, Marko; Kocijan, Ana; Berkopić, Lidija; Radić, Božo; Buljat, Gojko; Anić, Tomislav; Zoričić, Ivan; Bojanić, Ivan; Seiwerth, Sven; Sikirić, Predrag Više autora...

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Pevec, D., Novinščak, T., Brčić, L., Šipoš, K., Jukić, I., Starešinić, M. ... Sikirić, P. (2010). Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application. Medical science monitor, 16. (3), 81-88. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:264:547766

Pevec, Damira, et al. "Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application." Medical science monitor, vol. 16, br. 3, 2010, str. 81-88. https://urn.nsk.hr/urn:nbn:hr:264:547766

Pevec, Damira, Tomislac Novinščak, Luka Brčić, Kristijan Šipoš, Ivana Jukić, Mario Starešinić, Stjepan Miše, et al. "Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application." Medical science monitor 16, br. 3 (2010): 81-88. https://urn.nsk.hr/urn:nbn:hr:264:547766

Pevec, D., et al. (2010) 'Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application', Medical science monitor, 16(3), str. 81-88. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:264:547766 (Datum pristupa: 15.12.2024.)

Pevec D, Novinščak T, Brčić L, Šipoš K, Jukić I, Starešinić M, i sur.. Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application. Medical science monitor [Internet]. 2010. [pristupljeno 15.12.2024.];16(3):81-88. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:264:547766

D. Pevec, et al., "Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application", Medical science monitor, vol. 16, br. 3, str. 81-88, 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:264:547766. [Citirano: 15.12.2024.]

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Podaci o radu
Naslov (engleski)Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application
AutorDamira Pevec
AutorTomislac Novinščak
AutorLuka Brčić
MBZ: 272221
AutorKristijan Šipoš
AutorIvana Jukić
AutorMario Starešinić
AutorStjepan Miše
MBZ: 102751
AutorIva Brčić
MBZ: 296400
AutorDanijela Kolenc
MBZ: 272116
AutorRobert Kliček
AutorTihomir Banić
AutorMarko Sever
MBZ: 331893
AutorAna Kocijan
AutorLidija Berkopić
AutorBožo Radić
AutorGojko Buljat
MBZ: 38583
AutorTomislav Anić
MBZ: 158823
AutorIvan Zoričić
MBZ: 178566
AutorIvan Bojanić
MBZ: 171746
AutorSven Seiwerth
MBZ: 149676
AutorPredrag Sikirić
MBZ: 117454
Autorova ustanova(Klinička bolnica Merkur)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The effect of systemic and local peptide treatment effective in muscle contusion and then on counteraction of corticosteroid-induced impairment was tested. The pentadecapeptide BPC 157, given without a carrier, improved the healing of transected quadriceps muscle. It also improved muscle healing in rats with muscle crush injury when applied systemically or locally. Importantly, it counteracted corticosteroid-impairment in tendon to bone healing. Thus BPC 157 is proposed as an effective treatment that can improve muscle healing in spite of corticosteroid treatment. After the gastrocnemius muscle complex had been injured, rats received BPC 157 (intraperitoneally or locally as a cream) and/or 6alpha-methylprednisolone (intraperitoneally) only once (immediately after injury, sacrifice at 2 h) or once daily (final dose 24 hours before sacrifice and/or assessment procedure at days 1, 2, 4, 7, and 14). Muscle healing was evaluated functionally, macroscopically, and histologically. Without therapy, crushed gastrocnemius muscle complex controls showed limited improvement. 6alpha-methylprednisolone markedly aggravated healing. In contrast, BPC 157 induced faster muscle healing and full function restoration and improved muscle healing despite systemic corticosteroid treatment when given intraperitoneally or locally and demonstrated functionally, macroscopically, and histologically at all investigated intervals. BPC 157 completely reversed systemic corticosteroid-impaired muscle healing.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedical science monitor
Brojčani podacivol. 16, br. 3, str. 81-88
p-ISSN1234-1010
URN:NBNurn:nbn:hr:264:547766
Datum objave publikacije2010
URL dokumentahttps://medscimonit.com/abstract/index/idArt/878454
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-12-27 11:22:19