prikaz prve stranice dokumenta Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis
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Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis
U: Atherogenesis / Parrthasarathy, Sampath (ur.). INTECHWEB.ORG: InTech, 2012. str. 507-528. urn:nbn:hr:264:148910
Flegar-Meštrić, Zlata; Kardum Paro, Mirjana Mariana; Perkov, Sonja; Vidjak, Vinko; Grdić Rajković, Marija

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Flegar Meštrić, Z., Kardum Paro, M. M., Perkov, S., Vidjak, V. i Grdić Rajković, M. (2012). Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis. U S. Parrthasarathy, (Ur.), Atherogenesis (str. 507-528). INTECHWEB.ORG: InTech. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:264:148910

Flegar Meštrić, Zlata, et al. "Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis." Atherogenesis, Ur. Sampath Parrthasarathy, InTech, 2012, str. 507-528. https://urn.nsk.hr/urn:nbn:hr:264:148910

Flegar Meštrić, Zlata, Mirjana Mariana Kardum Paro, Sonja Perkov, Vinko Vidjak i Marija Grdić Rajković. "Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis." U Atherogenesis, ur. Sampath Parrthasarathy, 507-528. INTECHWEB.ORG: InTech, 2012. https://urn.nsk.hr/urn:nbn:hr:264:148910

Flegar Meštrić, Z., et al. (2012) 'Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis' u Parrthasarathy, S. (ur.) Atherogenesis INTECHWEB.ORG: InTech, str. 507-528. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:264:148910 (Datum pristupa: 02.11.2024.)

Flegar Meštrić Z, Kardum Paro MM, Perkov S, Vidjak V, Grdić Rajković M. Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis. U: S. Parrthasarathy, ur. Atherogenesis. INTECHWEB.ORG: InTech; 2012. Str. 507-528. [pristupljeno 02.11.2024.] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:264:148910

Z. Flegar Meštrić, M. M. Kardum Paro, S. Perkov, V. Vidjak i M. Grdić Rajković, "Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis", Atherogenesis, S. Parrthasarathy, Ur. INTECHWEB.ORG: InTech, 2012, str. 507-528. [Online] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:264:148910

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Podaci o radu
Naslov (engleski)Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis
AutorZlata Flegar-Meštrić
AutorMirjana Mariana Kardum Paro
AutorSonja Perkov
AutorVinko Vidjak
AutorMarija Grdić Rajković
UrednikSampath Parrthasarathy
Autorova ustanova(Klinička bolnica Merkur)
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The results of the present study show that basal and stimulated PON1 activities were significantly decreased in patient’s group with cerebrovascular stenosis ( group of patients with symptoms of cerebrovascular insufficiency and stenosis of carotid artery more than 50% of the lumen) versus control no-stenosis group (p<0.05). There were no statistically significant relationships between PON1 activity and lipid parameters (total cholesterol, LDL-cholesterol, HDL-cholesterol and tryacilglycerols), p>0.05. According to the obtained results the decreased PON1 activities in patients with cerebrovascular stenosis may cause decreased HDL antioxidant capacity and therefore contribute to the increase risk of the development of cerebrovascular atherosclerosis.However, there were no significant differences in genotype or allele frequencies of pon1 and pon2 genes between patients with stenosis of cerebral arteries and no-stenosis control group indicating that changes in paraoxonase activity are determined by both genetic and environmental factors. Our results show the most significant linear relationship between PAF-AH activity and total cholesterol and LDL-cholesterol ( p<0.001) in control no-stenosis group as well as in the group of patients with cerebrovascular stenosis. The median serum PAF-AH activity did not differ significantly between patients with cerebrovascular stenosis and control no-stenosis group (p>0, 05) while LDL standardized PAF-AH activity showed significant difference between both examined groups (p<0.0001). According to our results the LDL-standardized PAF-AH activity could be used as an additional discriminating biochemical indicator of cerebrovascular stenosis
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Poglavlje u knjizi
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov knjigeAtherogenesis
Brojčani podacistr. 507-528
ISBN978-953-307-992-9
URN:NBNurn:nbn:hr:264:148910
Datum objave publikacije2012-01
ProjektŠifra: 044-0061245-0551
Naziv (hrvatski): Novi biokemijski biljezi ateroskleroze u krvožilnim bolestima
Voditelj: Flegar-Meštrić, Zlata
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: 0,00 EUR
URL dokumentahttps://www.intechopen.com/books/atherogenesis
Vrsta resursaTekst
IzdavačInTech
Mjesto izdavanjaINTECHWEB.ORG
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2021-05-27 10:27:21