prikaz prve stranice dokumenta Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation
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Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation
U: Transplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013. Wiley, 2013. str. 138. urn:nbn:hr:264:049283
Mikulić, Danko; Knotek, Mladen; Gašparov, Slavko; Mrzljak, Anna; Škrtić, Anita; Čolić Cvrlje, Vesna; Jadrijević, Stipislav; Branislav, Kocman

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Mikulić, D., Knotek, M., Gašparov, S., Mrzljak, A., Škrtić, A., Čolić Cvrlje, V. ... Branislav, K. (2013). Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation. Transplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013 (str. 138). Wiley. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:264:049283

Mikulić, Danko, et al. "Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation." Transplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013, Wiley, 2013, str. 138. https://urn.nsk.hr/urn:nbn:hr:264:049283

Mikulić, Danko, Mladen Knotek, Slavko Gašparov, Anna Mrzljak, Anita Škrtić, Vesna Čolić Cvrlje, Stipislav Jadrijević i Kocman Branislav. "Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation." U Transplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013, 138. Wiley, 2013. Citirano 15.12.2024.. https://urn.nsk.hr/urn:nbn:hr:264:049283

Mikulić, D., et al. (2013) 'Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation', Transplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013, Wiley, str. 138. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:264:049283 (Datum pristupa: 15.12.2024.)

Mikulić D, Knotek M, Gašparov S, Mrzljak A, Škrtić A, Čolić Cvrlje V, i sur.. Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation. Transplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013. Wiley; 2013. Str. 138-138. [pristupljeno 15.12.2024.] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:264:049283

D. Mikulić, et al., "Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation", Transplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013 Wiley, 2013. [Online] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:264:049283 [Citirano: 15.12.2024.]

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Podaci o radu
Naslov (engleski)Tumor lymphocyte infiltration and prognosis in patients with hepatocellular carcinoma treated by liver transplantation
AutorDanko Mikulić
AutorMladen Knotek
AutorSlavko Gašparov
AutorAnna Mrzljak
AutorAnita Škrtić
AutorVesna Čolić Cvrlje
AutorStipislav Jadrijević
AutorKocman Branislav
Autorova ustanova(Klinička bolnica Merkur)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Background: Liver transplantation (LT) is an established treatment method in patients with hepatocellular carcinoma (HCC). However, a number of patients experience early recurrence and poor results as a consequence of aggressive tumor biology. Due to the ever increasing organ shortage, new biologic prognostic factors are necessary in order to stratify the patients regarding prognosis. Methods: 44 patients with HCC treated by LT were included in this retrospective study. Analyzed clinical and pathologic data include age, sex, number and size of tumors, tumor differentiation, presence of vascular invasion, adherence to Milan criteria, alpha-fetoprotein level. Immunostaining was used to assess the infiltration of CD3+, CD4+, CD8+ and Foxp3+ cells. Kaplan Meier curves and receiver operator characteristic (ROC) analysis were used to analyze recurrence free and overall survival. Results: Presence of microvascular invasion was found to be associated with HCC recurrence (p=0.035). Analysis of immune parameters showed that the patients with increased total lymphocyte infiltration measured by the number of tumor infiltrating CD3+ cells are less likely to experience recurrence (p=0.05). ROC curve analysis showed that patients with a CD4/CD8 ratio greater than 1 had better chances of recurrence free survival. Also, patients with lower numbers of infiltrating T reg cells were found less likely to experience HCC recurrence (p=0.025). Conclusion: Our results indicate that total lymphocyte infiltration, CD4/CD8 ratio and T reg infiltration have prognostic significance in HCC. These parameters could add valuable information to the presently used morphologic criteria in order to stratify HCC patients who benefit from liver transplantation.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Sažetak znanstvenog rada s konferencije (pozvano predavanje)
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov zbornikaTransplant International - Abstracts of the 16th ESOT Congress, Vienna, Austria, 8–11 September 2013
Brojčani podacivol. 26, br. Suppl. 2, str. 138
p-ISSN0934-0874
e-ISSN1432-2277
URN:NBNurn:nbn:hr:264:049283
Datum objave publikacije2013
SkupNaziv: 16th Congress of the European Society for Organ Transplantation
Kratica: 16th ESOT Congress
Lokacija: Beč, Austrija
Datum početka: 2013-09-08
Datum završetka: 2013-09-11
Vrsta izlaganja: Predavanje
URL dokumentahttps://onlinelibrary.wiley.com/toc/14322277/2013/26/s2
Vrsta resursaTekst
IzdavačWiley
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 3.0 (CC BY 3.0)
Datum i vrijeme pohrane2022-12-28 07:48:43